As of today, most of the top revenue generating drugs, across the globe, are biologics. During our research, we were able to identify 67 top selling biologics (revenues equal to or above USD 500 million in 2020). Top selling biologics market has so far been primarily led by industry players. Majority of industry players have taken a step towards investing their time and resources for the development of biologic therapies. Genentech, Amgen, Janssen Biotech, Sanofi and Novo Nordisk are amongst the major players in this domain. Biogen, AstraZeneca, Merck, Bristol Myers Squibb, GlaxoSmithKline, Alexion Pharmaceuticals, AbbVie and Novartis are other players that have entered the Top Selling Biologics domain in the past.
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It is worth highlighting that most of the therapies are monoclonal antibodies capture the highest share (54%) of the top selling biologics market. This can be attributed to the various advantages offered by them, including high reproducibility and specificity. It is also worth mentioning that these therapeutic modalities are being used for many cancer indications. Further, most of the top selling biologics are currently delivered via subcutaneous route of administration. However, most of the top selling biologics are available in the form of vials. This can be attributed to the better sterility assurance and reduced particle presence offered by such packaging formats.
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It is worth highlighting that most of the therapies are being developed against autoimmune and oncological disorders; Oncological indications targeted by biologics include colorectal cancer (6), Non-Small Cell Lung Cancer (3), Breast Cancer (3), Hepatocellular Carcinoma (3), bladder cancer (3), urothelial carcinoma (3), and melanoma (3).
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