Mass Spectrometry Analysis Service

Mass Spectrometry Analysis Services: Applications and Advancements in Analytical Chemistry

Mass spectrometry is a robust tool with diverse applications in multiple domains such as clinical research, proteomics and metabolomic studies, forensic toxicology, and pharma and biopharma evaluation. Mass spectrometry is a specialized technique requiring instrumental knowledge and expertise. Drug developers and pharmaceutical companies, particularly small and medium-sized companies, lack the expertise and initial investments for acquiring advanced and complicated instruments. Therefore, they often consider outsourcing mass spec services. 

Mass spectrometry service companies offer multiple bioanalytical solutions such as drug discovery and testing, biomarker services, protein identification, food contamination detection, carbon dating, radiological determination, pesticide residue analysis, and more. The current article discusses the application and advancements in Mass Spectrometry Analysis Service

Applications of mass spectrometry analysis services

Mass spectrometry can discover, identify, and quantify sample components. They have multiple applications, including:

  • In proteomics research, mass spectrometry can characterize proteins and protein complexes, identify post-translational modification, and evaluate peptide sequencing. 
  • During metabolomics studies, researchers apply mass spectrometry to screen and diagnose cancer patients, discover and profile novel biomarkers, analyze metabolic fingerprinting, generate biofuels, and profile metabolic disorders. 
  • In environmental analysis, researchers can test drinking water, screen and quantify pesticides, assess contaminated soil samples, monitor pollution levels, and analyze elemental heavy metals. 
  • Mass spectrometry service companies apply robust mass spectrometry to analyze the ADME profile of products, pharmacokinetic and pharmacodynamic evaluations, preclinical development, and metabolic screening. Mass spectrometry has multiple applications in clinical studies, such as drug therapy monitoring, disease screening, clinical drug development, identifying infectious agents, and analyzing peptides. 
  • In forensic analysis, mass spectrometry applications include trace evidence analysis, arson investigation, confirming drug abuse, and identifying explosive residues.

Advancement in mass spectrometry analysis

Mass spectrometry is widely employed in clinical laboratories with diverse applications, such as neonatal screening. Historically, mass spectrometry clinical applications have been restricted within specialist research studies. As a result, mass spectrometers have yet to expand their applications across different clinical settings and become a benchtop instrument for healthcare providers. However, continual advancements in mass spectrometry instruments and their ease of use, coupled with cost-effective tools, have helped increase the availability of mass spectrometers for clinical assessment. Technological initiatives have led to an increase in clinical mass spectrometry applications, with a 10-fold growth in the last 20 years. 

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Besides, advancements in mass spectrometers are not limited to the instrumental setup. To make mass spectrometers a routine detection tool, there are significant efforts to refine sample collection methods to decrease the required technical expertise and associated experimental costs. These improvements have the potential to provide robust in-community sampling and non-invasive and rapid methods during point-of-care treatment. Efforts in MS-based development and applications are the primary reason for the continual growth of mass spectrometers with the potential of becoming a primary technology in hospitals and research institutions

In Conclusion

Mass spectrometry-based analysis has multiple applications in biomedical and pharmaceutical research. With advances in mass spectrometry instrumentation and applications, the demand for mass spectrometry analysis services will skyrocket in the coming years. However, robust method development and validation will remain crucial for acquiring rapid, reliable, and accurate results.